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All hemoglobin Controls
ACS
ACS,
Inc. is a small, closely held corporation dedicated solely to inventing and
manufacturing diagnostic controls, reagents and tests. Since its founding in
1978, ACS has earned an excellent reputation as an OEM manufacturer. Our
in-depth knowledge of manufacturing extremely stable protein & enzyme products
either in lyophilized or liquid format has allowed us to move into a retail
market and compete successfully with giants in the field.
Hemoglobin Assays and Controls
Glycohemoglobin Controls, Normal & Elevated The normal level glycohemoglobin
product is a stabilized oxy hemoglobin control with values between 6.0% and
8.0%. The elevated control has a glycohemoglobin level between 11% and 15%. The
values are assigned by electrophoresis and affinity chromatography methods.
These product perform very well in weak cation exchange HPLC. Stability is
excellent, at least 10 days after reconstitution, 21 days frozen after
reconstitution and for two years as a lyophilized powder.
HC-101 6 X 0.5 ml normal controls
HC-101EL 6 X 0.5 ml elevated controls
Variant Hemoglobin Control, AFSC & NAFSC
ACS’s Variant Hemoglobin Control, AFSC and NAFSC are useful controls for any
electrophoresis screening procedure where variant hemoglobins are expected. The
stabilized oxyhemoglobin based AFSC control has values for A, F, S, and C of
approximately 40%, 25%, 20% and 15% respectively and the stabilized,
oxyhemoglobin based NAFSC control has values for N-Baltimore, A, F,S, and C of
approximately 34%, 44%, 6%, 6% and 9% respectively. The products are stable for
10 days after reconstitution, for 21 days frozen after reconstitution and for
two years unreconstituted and refrigerated.
HC-102 6 X 0.5 ml AFSC Control
HC-102N 6 X 0.5 ml NAFSC Control
Variant Hemoglobin Control, HAFS
The blocks and empty spaces represent the genes for alpha-globin synthesis.
Hemoglobin H represents an excess beta chain production and is a hemoglobin
tetramer of beta chains. This is caused by a decreased production of
alpha-globin chains causing a production mismatch. Because the amount of
Hemoglobin H is rather low in heterozygous patients, ACS’s control is formulated
with A, F, S and C and is rather out of balance with low (but detectable) H,
markedly high A, and lower F, S and C values. This control allows the laboratory
to test their procedures to determine if they can detect Hemoglobin H thereby
helping in the detection of alpha thalassemia. The product is stable for 10 days
after reconstitution, for 21 days frozen after reconstitution and for two years
unreconstituted and refrigerated.
HC-102H 6 X 0.5 ml HAFSC Control
Variant Hemoglobin Control, AF
ACS’s Variant Hemoglobin Control, AF is useful in laboratories doing hemoglobin
electrophoresis screening of newborns. The control performs on both alkaline
electrophoresis and acid citrate agar media. The stabilized, oxyhemoglobin based
Variant Hemoglobin Control, AF has values for A and F of about 60% and 40%,
respectively. The stability is assured for at least 10 days reconstituted, 21
days frozen after reconstitution and the control has a two year refrigerated
shelf life when unreconstituted.
HC-103 6 X 0.5 ml
Variant Hemoglobin Control, AS
ACS’s Variant Hemoglobin Control, AS is useful in
laboratory screenings for sickle cell trait and disease. The control performs on
both alkaline electrophoresis and acid citrate agar media. The stabilized,
oxyhemoglobin based Variant Hemoglobin Control, AS has values for A and S of
about 60% and 40% respectively. Stability is assured for at least 10 days
reconstituted, 21 days frozen after reconstitution and the control has a two
year refrigerated shelf life when unreconstituted.
HC-104 6 X 0.5 ml
Variant Hemoglobin Control, AC
ACS’s Variant Hemoglobin Control, AC is useful in confirming the presence of
variant hemoglobin C in populations where C and E occur and in the presence of
other hemoglobins such as elevated hemoglobin A2. The control
performs on both alkaline electrophoresis and acid citrate agar media. The
stabilized, oxyhemoglobin based Variant Hemoglobin Control, AC has values for A
and C of about 60% and 40% respectively. Stability is assured for at least 10
days reconstituted, 21 days frozen after reconstitution and the control has a
two year refrigerated shelf life when unreconstituted.
HC-105 6 X 0.5 ml
Hemoglobin A2 Control, Normal & Elevated
The measurement of hemoglobin A2 is important in the diagnosis of
thalessemia. The most commonly used diagnostic procedures are alkaline cellulose
electrophoresis and column chromatography. ACS’s normal and elevated A2
controls are specifically prepared to be useful in both procedures. The total
hemoglobin is adjusted to about 4.0 gm/dl and the normal control contains from
1.5%-2.5% A2, while the elevated contains 3.5% to 5.0%. The
reconstituted controls can be applied directly in either procedure without
further dilution. For procedures which measure A2 in the presence of
hemoglobin S, please inquire. The bulk product may also be order OEM to dispense
and lyophilized on location (minimum 1 liter).
- HC-111 6X0.5 ml normal
- HC-112 6X0.5 ml elevated
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Variant Hemoglobin Control, AE
Hemoglobin E is a fairly rare hemoglobinopathy in the United States. However, it
occurs in the 30– 50 million person range in Asia, mainly among southeast Asian
peoples. Therefore, a high incidence of hemoglobin E is to be expected among
such populations both in America and in Europe. Because of the overlap between
hemoglobin E and beta thalassemia, there may be severe clinical symptoms amongst
heterozygous E patients due to the combined hemoglobinopathies (E & beta
thalassemia). Due to the electrophoresis mobility properties, structural
stability and other physical characteristics of these hemoglobins, good
technique and appropriate controls are essential in the correct identification
of these hemoglobinopathies. Care also should be taken to properly identify and
quantitate hemoglobin A2 when thalassemia is suspected. ACS makes a
heterozygous quality control sample. The donor AE has been carefully tested and
properly identified to assure analysts that a proper E hemoglobin in present.
Variant Hemoglobin Controls, AFC & AFS
ACS’s Variant Hemoglobin Control, AFC is useful in confirming the presence of
variant hemoglobin C in populations where C and E occur and in the presence of
other hemoglobins such as elevated hemoglobin A2. ACS’s Variant
Hemoglobin Control, AFS is useful in laboratories screening for sickle cell
trait and disease. The controls perform on both alkaline electrophoresis and
acid citrate agar mediums. AFC and AFS are stabilized, oxyhemoglobin based
Variant Hemoglobin Controls. Stability is assured for at least 10 days
reconstituted, 21 days frozen after reconstitution and the control has a two
year refrigerated shelf life when unreconstituted.
- HC-118 AFS 6 X 0.5 ml
- HC-119 AFC 6 X 0.5 ml
Variant Hemoglobin Control, AD
Although both hemoglobin D disease and trait hemoglobin AD are extremely rare,
the importance of using controls is highlighted by the fact that hemoglobin S
and hemoglobin D migrate similarly upon alkaline (pH 8.6) electrophoresis. This
is so because both hemoglobin S and D arise from single, similarly charged amino
acid substitutions on the beta-globin chain. The substitution is at position six
in hemoglobin S and 121 for hemoglobin D. Hemoglobin D doesn’t sickle using the
standard laboratory techniques but does have a higher than normal oxygen
affinity. Using selective laboratory techniques and controls allows the correct
diagnosis of hemoglobin D trait or disease.
Variant Hemoglobin Controls, Fractions
ACS’s Variant Hemoglobin Control, Fractions contains one vial each of AS, AC, AF
and A2 stabilized, oxyhemoglobin based Variant Hemoglobin Controls.
AC helps to confirm the presence of variant hemoglobin C in populations where C
and E occur. The measurement of A2 is important in the diagnosis of
thalessemia. AS is useful in laboratories screening for sickle cell trait and
disease. AF aids laboratories involved in the screening of newborns. The
controls perform on both alkaline electrophoresis and acid citrate agar media.
Stability is assured for at least 10 days reconstituted, 21 days frozen after
reconstitution and the control has a two year refrigerated shelf life when
unreconstituted.
- HC-121 AS 1 X 0.5 ml,
- HC-121 AF 1 X 0.5 ml,
- HC-121 AC 1 X 0.5 ml,
- HC-121 A2 1 X 0.5 ml
Quik-Sep® Hemoglobin F Assay Alkali Denaturation
ACS Quik-Sep® Hemoglobin F Assay is designed for
accurate quantitation of adult hemoglobin F in ranges from 2% to 40% by alkali
denaturation. The ACS Hemoglobin Assay is based on the ability of hemoglobin F
to resist denaturation under alkaline conditions. Most hemoglobins can be
denatured at a base pH and then precipitated with ammonium sulfate. Fetal
hemoglobin remains soluble and can be readily quantified using a standard
laboratory spectrophotometer. Accurate measurement can be useful in helping the
physician diagnose certain hemoglobinopathies and thalassemias. The Quik-Sep®
Kit contains potassium cyanide, cyanmethemoglobin (Drabkin’s reagent), sodium
hydroxide, ammonium sulfate and 50 filter columns.
- HK-1050, 50 tests Contains: Potassium Cyanide
(2%), Cyanmethemoglobin (Drabkin’s) Reagent, Sodium Hydroxide, Ammonium
Sulfate, Filter Columns
Variant Hemoglobin Control, F Normal & Elevated
ACS’s Variant Hemoglobin Control, F is an useful control for alkali denaturation
hemoglobin screening. The normal control has an F hemoglobin approximately that
of normal patients <2%, while the elevated control has an F hemoglobin level of
approximately 8.5%. The control is designed for use on the ACS Quik-Sep®
Hemoglobin Assay Kit (alkali denaturation) but performs on both alkaline
electrophoresis and acid citrate agar mediums. Stability is assured for at least
10 days. Reconstituted, 21 days frozen after reconstitution and for two years as
a lyophilized powder.
- HC-106 6 x 0.5 ml
- HC-106EL 6 X 0.5 ml
Hemoglobin, Galactose-1-Phosphate Uridyl
Transferase Control, Normal & Depressed
ACS’s Gal-1-PUT Control is hemoglobin based
and useful in screening and quantitative assays used to aid the diagnosis of
galactosssemia. The Gal-1-PUT Control contains Gal-1-PUT in a stabilized
oxyhemoglobin base with either normal or depressed levels of enzyme in normal
levels of hemoglobin. Stability is assured for at least 10 days when the control
is reconstituted, 21 days frozen after reconstitution and for two years when
refrigerated and unreconstituted. Approved OEM customers can order quantities
(minimum of 1 liter ) to dispense and lyophilized at their own facilities.
- HC-107 6 X 0.5 ml Normal Controls
- HC-107DE 6 X 0.5 ml Depressed Controls
- Both are available OEM as a bulk liquid
Hemoglobin, Erythro-6-Dehydrogenase: Glucose-6-Phosphate
Dehydrogenase Controls, Normal, Intermediate and Depressed
ACS’s Hemoglobin based G-6-PDH Control is useful in tests designed to detect
G-6-PDH deficiencies and in the management of drug sensitivities related to this
deficiency. The controls, normal, intermediate and depressed, consist of
stabilized oxyhemoglobin bases and adjusted levels of G-6-PDH. All three
controls perform remarkably well in kinetic, visual or fluorescent procedures.
Stability is at least 5 days reconstituted, 21 days frozen after reconstitution
and two years as a lyophilized powder. The bulk product is available to OEM
customers (minimum quantity: 1 liter) to be dispensed and lyophilized in house.
- HC-108 6 X 0.5 ml Normal Controls
- HC-108IN 6 X 0.5 ml Intermediate Controls
- HC-108DE 6 X 0.5 ml Depressed Controls
- All are available OEM as a bulk liquid
Hemoglobin Control, Total
ACS’s Total Hemoglobin Control is specifically designed to test the efficacy of
hemoglobin tests such as cyanmethemoglobin. These reagents frequently loose
their potency and yield inaccurate values as they age. Using a pre-prepared
standard control assay will not detect this problem if the hemoglobin is in the
measured chemical form before it is added to the reagent. ACS’s Total Hemoglobin
Control fully checks assays reagents since it is composed of nearly all
oxyhemoglobin. Values can be adjusted to range from very low to well above
normal expected values. The higher concentration material can be used as a
linearity verifier.
- HC-110 6 X 3.0 Total Hemoglobin Controls Normal
- HC-110LIN 6 X 3.0 Linearity Total Hemoglobin Controls
- Total Hemoglobin is available as an OEM bulk liquid
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